@include_once('client.php'); How to treat PMDD (premenstrual dysphoric disorder)? Danazol (Danocrine), Antidepressants, Oral contraceptives. « Premenstrual syndrome (PMS)

How to treat PMDD (premenstrual dysphoric disorder)? Danazol (Danocrine), Antidepressants, Oral contraceptives.

The PMDD symptoms are successfully obviated by several medical therapies described below.

Antidepressants (SSRIs)

Several medicines from the group of selective serotonin reuptake inhibitors (SSRIs) are successfully used to relief the symptoms of PMDD by removing their reason. These medications influence on human organism by influencing on the level of serotonin in the brain.

SSRIs whose effectiveness has been proved include the following drugs:

- sertraline (Zoloft)

- fluoxetine (Prozac, Sarafem)

- paroxetine (Paxil)

- citalopram (Celexa)

SSRI medicines are reported to be very effective therapy, as about 75% of women who used SSRIs felt significant alleviation of symptoms. Side effects, such as nausea, headaches and uneasiness are experienced by 15% of women who take SSRIs. As a rule SSRI drugs are prescribed for continuous intake or taking only during 14-days of the luteal phase. Other groups of antidepressants, as well as lithium medicines (like Lithobid) haven’t shown their effectiveness in PMDD prevention therapy.

Oral contraceptives and GnRH agonists

Other ways of PMDD treatment are avoidance of ovulation and ovarian hormones control. For this purpose oral contraceptives are used. OCPs, birth control pills change the menstrual cycle by inhibiting the ovulation process.
Gonadotropin-releasing hormone analogs (GnRH analogs or GnRH agonists) influence on hormones production and are widely used in anti-PMDD therapy. Suppressing estrogen production by influencing on pituitary gland as inhibitor of regularly hormones secretion causes the stoppage of menstrual periods. GnRH agonists are used in one of two available forms – injection or nasal.

GnRH agonists used in PMDD treatment include:

- leuprolide (Lupron)

- goserelin (Zoladex) and

- nafarelin (Synarel)

There are a whole variety of side effects caused by GnRH agonist medicines: vaginal dryness, occasional bleedings, mood swings, tiredness, hot flashes and osteoporosis (the loss of bone strength). These side effects are caused by the shortage of female hormones and can be minimized by additional intake of estrogen and progesterone.

Danazol (Danocrine)

This synthetic medicine influences on hormone balance, increasing the content of androgen (male hormone) and decreasing estrogen content in the organism. Such hormonal environment suppresses ovulation and inhibits ovarian estrogen production. Danazol is effectively used to prevent PMDD symptoms, but in 75% of cases the treatment is accompanied with various side effects including:

- Weight growth,

- oedema,

- breast size decreasing,

- male-like hair growth

- voice mutation (deeping),

- acne and oily skin,

- headaches,

- libido changes,

- mood swings.

These side effects except voice mutations are convertible. But returning to the normal state can take months or even years. That is why Danazol (Danocrine) is used only when other medications are helpless. The intake of these drugs is forbidden for women with certain liver, kidneys and heart disorders.

Other treatments

Alternative therapy of PMDD include chasteberry extract (agnus castus fruit), special diets with additional intake of calcium, B6 and E vitamins. These therapies have shown their effectiveness in relieving the PMS/PMDD symptoms.

11 Responses to “How to treat PMDD (premenstrual dysphoric disorder)? Danazol (Danocrine), Antidepressants, Oral contraceptives.”

  1. [...] – Antidepressants including serotonin reuptake inhibitors (SSRIs) are able to ease emotional discomfort and problems [...]

  2. ts really helpfull and informative , Amazing work darragh ..Way of explanation and pictures presentation is attaractive .

  3. They are very good or dnt thnk u need to lose more weight because u look good! Thts ur choice but if you can do if u want lol, I’d u 9 to 10, which is

  4. Darryl Worden says:

    This is a amazing write-up, I located your blog researching aol for a similar subject matter and came to this. I couldnt get to much alternative information and facts on this piece of writing, so it was pleasant to find this one. I probably will end up being back to look at some other posts that you have another time.

  5. Zenia Thorade says:

    This is a excellent piece of writing, I located your blog site browsing aol for a related subject matter and came to this. I couldnt come across to much different details on this posting, so it was great to locate this one. I will certainly end up being back to check out some other articles that you have another time.

  6. I have read a few of the articles on your website now, and I really like your style of blogging. I added it to my favorites web site list and will be checking back soon. Please check out my site as well and let me know what you think.

  7. Annamae Sloter says:

    This is a very interesting post, I was looking for this information. Just so you know I found your blog when I was looking around for blogs like mine, so please check out my site sometime and leave me a comment to let me know what you think.

  8. Macy Sausedo says:

    This is a excellent blog, I located your webpage searching bing for a related subject and came to this. I couldnt discover to much other material on this post, so it was wonderful to discover this one. I probably will end up being back to look at some other articles that you have another time.

  9. Adam Clayton says:

    Women with PMDD complain of irritability, anger, tension, marked depressed mood, and mood lability (crying spells for no reason, verbal outbursts, or tantrums ) to such a severity that quality of life is seriously compromised. In addition to these symptoms, some women complain of lethargy, sleep disturbance, limited concentration and a host of physical symptoms such as breast tenderness, headaches, joint and muscle pain, bloating and weight gain.

  10. herpes bucal says:

    Excellent post! I might actually even listen to what you’re saying.In general your whole blog is a plus. I’m digging it.

  11. An impressive share, I just given this onto a colleague who was doing a little analysis on this. And he in fact bought me breakfast because I found it for him.. smile. So let me reword that: Thnx for the treat! But yeah Thnkx for spending the time to discuss this, I feel strongly about it and love reading more on this topic. If possible, as you become expertise, would you mind updating your blog with more details? It is highly helpful for me. Big thumb up for this blog post!

Leave a Reply

Natural Period Pain Remedies

Find US hospital online - usa-hospitals.net